INVESTIGADORES
LEWKOWICZ Elizabeth Sandra
artículos
Título:
Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides
Autor/es:
JORGE TRELLES; ANA LAURA VALINO; VALERIA RUNZA; ELIZABETH LEWKOWICZ; ADOLFO IRIBARREN
Revista:
BIOTECHNOLOGY LETTERS
Editorial:
Springer
Referencias:
Año: 2005 vol. 27 p. 759 - 763
ISSN:
0141-5492
Resumen:
>Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose.
