Methyltransferases: Functions and Applications

ABDELRAHEEM, EMAN; THAIR, BENJAMIN; VARELA, ROMINA FERNÁNDEZ; JOCKMANN, EMELY; POPADI?, DÉSIRÉE; HAILES, HELEN C.; WARD, JOHN M.; IRIBARREN, ADOLFO M.; LEWKOWICZ, ELIZABETH S.; ANDEXER, JENNIFER N.; HAGEDOORN, PETER-LEON; HANEFELD, ULF

CHEMBIOCHEM

WILEY-V C H VERLAG GMBH

Año: 2022 vol. 23

1439-4227

In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.