High increment of triglycerols with ether linkages in the retina during anoxia

GIUSTO, N.M.; BAZÁN, N.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 1973 vol. 55 p. 515 - 521

0006-291X

In the bovine retina incubated during 90 min in a medium lacking glucose without preoxygenation and gassed with O2-free N2 a striking rise in triglycerides with ether bonds was found. NaF and 2,4-DNP decrease the production of these molecules while cycloheximide (1.78mM) completely abolishes the phenomenon. The free fatty acid pool increases about six-fold and this rise is not affected by the inhibitors. Bovine serum albumin stimulates the free fatty acid and triglycerols production. The amount of these lipids decrease by further incubation under normoxia in the presence of glucose.