Regulation of Phosphatidic Acid Metabolism by Sphingolipids

SUSANA J. PASQUARÉ; VIRGINIA GAVEGLIO; NORMA M. GIUSTO

Journal of Lipids

Editorial: Hindawi Publishing Corporation

Año: 2011 vol. 2011 p. 1 - 18

2090-3030

This paper explores the way ceramide, sphingosine, ceramide 1-phosphate, and sphingosine 1-phosphate modulate the generationof second lipid messengers from phosphatidic acid in two experimental models of the central nervous system: in vertebrate rodoutersegmentspreparedfromdark-adaptedretinasaswellasinrod outer segments prepared fromlight-adapted retinas and in ratcerebral cortex synaptosomes under physiological aging conditions. Particular attention is paid to lipid phosphate phosphatase,diacylglycerol lipase, and monoacylglycerol lipase. Based on the findings reported in this paper, it can be concluded that proteinsrelated to phototransduction phenomena are involved in the effects derived from sphingosine 1-phosphate/sphingosine orceramide 1-phosphate/ceramide and that age-related changes occur in the metabolism of phosphatidic acid from cerebral cortexsynaptosomes in the presence of either sphingosine 1-phosphate/sphingosine or ceramide 1-phosphate/ceramide. The presentpaper demonstrates, in two differentmodels of central nervous system, how sphingolipids influence phosphatidic acidmetabolismunder different physiological conditions such as light and aging.oduction by specific phosphatases and LPPs that regenerate Sph or