DISCOVERY OF A NOVEL Trypanosoma cruzi BROMODOMAIN INHIBITOR USING PROTEIN-DIRECTED DYNAMIC COVALENT CHEMISTRY

ALONSO, VICTORIA L.; GARCÍA, PAULA; ESCALANTE, ANDREA M.; SERRA, ESTEBAN; FURLAN, RICARDO L. E.

CABA

Encuentro; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

SAIB, SAIC, SAI, SAA, SAB, SAFE, SAFIS, SAH, SAP

Bromodomains are the only protein domains capable of recognizingand interacting with acetylated lysines. Trypanosoma cruzi,the causal agent of Chagas disease, presents an atypical bromodomain(TcBDF3) that interacts with acetylated α-tubulin present in thecytoskeleton and flagella of this parasite. TcBDF3 is an interestingtarget for the development of new trypanocidal drugs that interruptthe Bromodomain-acetylated ligand interaction due to its essentialityin the differentiation of T. cruzi.