Extractos modificados como fuente alternativa de compuestos bioactivos

FURLAN, RLE; MENDEZ, L; SALAZAR, MO; RAMALLO, IA

Santiago de Compostela

Simposio; II Simposio Iberoamericano de Química Orgánica; 2010

Diferentes Sociedades de Química Iberoamericanas

The access to libraries of molecules with interesting biomolecular properties is a limiting step in the drug discovery process.  By virtue of a long molecular evolution process, natural products are recognized as biologically validated starting points in structural space for library development. We discuss here a strategy to generate natural product-like libraries. Semi synthetic mixtures of compounds are produced by diversification of natural product extracts through chemical transformation of common chemical functionalities in natural products into chemical functionalities rarely found in nature