INVESTIGADORES
FURLAN Ricardo Luis Eugenio
capítulos de libros
Título:
Trimethyltin Hydroxide
Autor/es:
FURLAN, RLE; MATA, EG
Libro:
Encyclopedia of Reagents for Organic Synthesis
Editorial:
Wiley
Referencias:
Lugar: Amsterdam; Año: 2011; p. 1 - 3
Resumen:
Trimethyltin hydroxide (TMTOH) has proven to be a very efficient reagent for the saponification of nonhindered alkyl esters under mild conditions. Compared to classical saponification agents (LiOH, NaOH, K2CO3, Ba(OH)2, Cs2CO3, etc.), TMTOH is less prone to produce epimerization of sensitive stereocenters, or lead to the degradation of base-sensitive functional groups. In fact, the appearance of this very convenient hydrolytic reagent has led to a widespread use of methyl esters for the protection of carboxylic acids.
