INVESTIGADORES
FURLAN Ricardo Luis Eugenio
artículos
Título:
A bioactive Trypanosoma cruzi bromodomain inhibitor from chemically engineered extracts
Autor/es:
RAMALLO, IA; ALONSO, V; RUA, F; SERRA, E; FURLAN, RLE
Revista:
ACS Combinatorial Science
Editorial:
American Chemical Society
Referencias:
Lugar: Washington, DC; Año: 2018
ISSN:
2156-8952
Resumen:
A set of chemically engineered extracts enriched in compounds including N?N and N?O fragments in their structures was prepared. Bromodomain binding screening and bioguided fractionation led to the identification of one oxime hit that interacts with TcBDF3 with affinity in the submicromolar range and that shows interesting antiparasitic properties against the different life cycle stages of T. cruzi.
