INVESTIGADORES
FURLAN Ricardo Luis Eugenio
artículos
Título:
Host Amplification in a Dithioacetal-Based Dynamic Covalent Library
Autor/es:
ORRILLO, AG; ESCALANTE, AM; FURLAN, RLE
Revista:
ORGANIC LETTERS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2017 vol. 19 p. 1446 - 1449
ISSN:
1523-7060
Resumen:
Molecular amplification in a dithioacetal-based dynamic library is described for the first time. The homatropine induced selection; amplification and isolation of one cyclophane host demonstrate the utility of dithioacetal exchange for preparing responsive dynamic libraries. Nuclear magnetic resonance and isothermal titration calorimetry analysis suggest that the amplified macrocycle forms a 1:1 complex with the template. This is the first report about a host:guest system involving a dithioacetal cyclophane.
