INVESTIGADORES
FURLAN Ricardo Luis Eugenio
artículos
Título:
Correlation of Antifungal Activity of Selected -substituted Acetophenones with their Keto-Enol Tautomerization Energy.
Autor/es:
RODRIGUEZ, AM; GIANNINI, F; SUVIRE, F; BALDONI, H; FURLAN, RLE; ZACCHINO, SA; BEKE, G; MATYUS, P; ENRIZ, RD; CSIZMADIA, I
Revista:
JOURNAL OF MOLECULAR STRUCTURE THEOCHEM
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2000 vol. 504 p. 35 - 50
ISSN:
0166-1280
Resumen:
The antifungal activity, measured as minimum inhibitory concentration (MIC) of selected a-substituted acetophenones, showed a linear correlation with the computed enolization energies (DEenolization). This suggested that ketoenol tautomerization plays a significant role in the action mechanism of these a-substituted acetophenones. In order to corroborate this conclusion, two related compounds were synthesized which could not undergo ketoenol tautomerization. Their bioassay proved them to be completely inactive.
