INVESTIGADORES
FREIRE ESPELETA Eleonora
artículos
Título:
Zn thiosacharinates: From ionic to polymeric structures. Synthesis, characterization and cell proliferation inhibition studies
Autor/es:
FERMIN DELGADO; ELEONORA FREIRE; RICARDO BAGGIO; VERÓNICA GONZÁLE PARDO; VIVIANA DORN; MARIANA DENNEHY
Revista:
INORGANICA CHIMICA ACTA
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2018 vol. 479 p. 266 - 274
ISSN:
0020-1693
Resumen:
A series of Zn thiosacharinates complexes with nitrogen donor co-ligands were synthesized: [Zn(tsac)2(o-phen)], [Zn(tsac)2(TMDP)]n, [(4,40-bipy)H2][Zn(tsac)4] [Zn(tsac)2(2,20-bipy)], [Zn(tsac)2(2,20-bquin)],(tsac, thiosaccharinate anion: 1,1-dioxo-1,2-benzisothiazole-3-thiolato, C7H4NO2S2, o-phen: 1,100-phenantroline, TMDP: trimethylenedipyridine, 2,20-bipy: 2,20-bipyridine, 4,40-bipy: 4,40-bipyridine, 2,20-bquin: 2,20-biquinoline). They were fully characterized by means of FTIR, 13C and 1H NMR, elementalanalysis and conductivity measurements. Three of them, [Zn(tsac)2(o-phen)], [(4,40-bipy)H2][Zn(tsac)4],[Zn(tsac)2(TMDP)]n were also characterized by X-ray single crystal diffractometry and their crystalstructures are described herein. DFT geometry optimization for the [Zn(tsac)2(o-phen)] complex wasperformed and its vibrational spectra was predicted. Moreover, we studied the effects of the fivecomplexes on cell proliferation, thus providing preliminary evidence for their therapeutic potential asanti-cancer drugs.
