Aripiprazole salts. I. Aripiprazole nitrate.

ELEONORA FREIRE; GRISELDA POLLA; GRISELDA POLLA

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2012 vol. 68 p. 170 - 173

0108-2701

The crystal structure of aripiprazole nitrate (systematic name:4-(2,3-dichlorophenyl)-1-{4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl}piperazin-1-ium nitrate), C23H28Cl2N3O2+-NO3 or AripH+NO3, is presented and the moleculecompared with the aripiprazole molecules reported so far inthe literature. Bond distances and angles appear very similar,except for a slight lengthening of the C—NH distancesinvolving the protonated N atom, and the main differences areto be found in the molecular spatial arrangement (revealed bythe sequence of torsion angles) and the intermolecularinteractions (resulting from structural elements specific tothis structure, viz. the nitrate counter-ions on one hand andthe extra protons on the other hand as hydrogen-bondacceptors and donors, respectively). The result is theformation of [100] strips, laterally linked by weak – andC—Cl   interactions, leading to a family of undulatingsheets parallel to (010).