STUDY OF SREBP1 AND SERBP2 IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM HYPERCHOLESTEROLEMIC RABBITS

SAEZ ALDANA; FUNES, ABI K.; COLOMBO REGINA; MUSSI JESICA; FORNES MW.; SAEZ LANCELLOTTI, T.E.; FORNES MW.; BOARELLI P V

Mar del Plata

Congreso; SAIC 2018; 2018

Peripheral blood mononuclear cells are a possible biomarker thatcould reveal molecular alterations before the development of thedisease.􀀷􀁋􀁈􀁕􀁈􀁉􀁒􀁕􀁈􀀏􀀃􀁗􀁋􀁈􀀃􀁒􀁅􀁍􀁈􀁆􀁗􀁌􀁙􀁈􀀃􀁒􀁉􀀃􀁗􀁋􀁈􀀃􀁓􀁕􀁈􀁖􀁈􀁑􀁗􀀃􀁌􀁑􀁙􀁈􀁖􀁗􀁌􀁊􀁄􀁗􀁌􀁒􀁑􀀃􀁌􀁖􀀃􀁗􀁒􀀃􀁖􀁗􀁘􀁇􀁜􀀃􀁐􀁒-􀁏􀁈􀁆􀁘􀁏􀁄􀁕􀀃 􀁄􀁑􀁇􀀃 􀁊􀁈􀁑􀁈􀁗􀁌􀁆􀀃 􀁆􀁋􀁄􀁑􀁊􀁈􀁖􀀃 􀁗􀁋􀁄􀁗􀀃 􀁌􀁑􀁇􀁌􀁆􀁄􀁗􀁈􀀃 􀁐􀁈􀁗􀁄􀁅􀁒􀁏􀁌􀁆􀀃 􀁐􀁒􀁇􀁌􀃀􀁆􀁄􀁗􀁌􀁒􀁑􀁖􀀃􀁈􀁙􀁈􀁑􀀃􀁚􀁌􀁗􀁋􀀃􀁑􀁒􀁕􀁐􀁄􀁏􀀃􀁅􀁌􀁒􀁆􀁋􀁈􀁐􀁌􀁆􀁄􀁏􀀃􀁙􀁄􀁏􀁘􀁈􀁖􀀑􀀃􀀶􀀨􀀵􀀥􀀳􀀔􀀃􀁄􀁑􀁇􀀃􀀶􀀨􀀵􀀥􀀳􀀕􀀃􀀃􀀋􀁖􀁗􀁈􀁕􀁒􀁏􀀃􀁕􀁈􀁊􀁘􀁏􀁄􀁗􀁒􀁕􀁜􀀃􀁈􀁏􀁈􀁐􀁈􀁑􀁗􀀃􀁅􀁌􀁑􀁇􀁌􀁑􀁊􀀃􀁓􀁕􀁒􀁗􀁈􀁌􀁑􀀌􀀃􀁄􀁕􀁈􀀃􀁓􀁕􀁒􀁗􀁈􀁌􀁑􀁖􀀃􀁄􀁖􀁖􀁒􀁆􀁌􀁄􀁗􀁈􀁇􀀃􀁚􀁌􀁗􀁋􀀃􀁏􀁌-pogenesis and regulated by the levels of insulinemia and cholesterolrespectively. These molecules can expressed in peripheral blood􀁐􀁒􀁑􀁒􀁑􀁘􀁆􀁏􀁈􀁄􀁕􀀃􀁆􀁈􀁏􀁏􀁖􀀑􀀃􀀷􀁋􀁌􀁖􀀃􀁄􀁏􀁏􀁒􀁚􀁖􀀃􀁖􀁗􀁘􀁇􀁜􀀃􀁗􀁌􀁖􀁖􀁘􀁈􀀃􀁆􀁋􀁄􀁑􀁊􀁈􀁖􀀃􀁚􀁌􀁗􀁋􀁒􀁘􀁗􀀃􀁕􀁈􀁖􀁒􀁕􀁗-ing to biopsies.􀀬􀁑􀀃􀁗􀁋􀁌􀁖􀀃􀁖􀁗􀁘􀁇􀁜􀀏􀀃􀁒􀁑􀁈􀀃􀁆􀁒􀁑􀁗􀁕􀁒􀁏􀀃􀁊􀁕􀁒􀁘􀁓􀀃􀁒􀁉􀀃􀀱􀁈􀁚􀀃􀀽􀁈􀁄􀁏􀁄􀁑􀁇􀀃􀁕􀁄􀁅􀁅􀁌􀁗􀁖􀀃􀁚􀁄􀁖􀀃􀁉􀁈􀁇􀀃􀁚􀁌􀁗􀁋􀀃balanced feed (C) and another group received the same balanced􀁉􀁈􀁈􀁇􀀃􀁖􀁘􀁓􀁓􀁏􀁈􀁐􀁈􀁑􀁗􀁈􀁇􀀃􀁚􀁌􀁗􀁋􀀃􀀔􀀚􀀈􀀃􀁉􀁄􀁗􀀃􀀋􀀩􀀌􀀑􀀃􀀷􀁋􀁈􀁖􀁈􀀃􀁄􀁑􀁌􀁐􀁄􀁏􀁖􀀃􀁇􀁌􀁇􀀃􀁑􀁒􀁗􀀃􀁕􀁈􀁆􀁈􀁌􀁙􀁈􀀃fructose overload, maintaining constant concentrations of carbohydratesand protein in both groups.􀀬􀁑􀀃 􀁅􀁌􀁒􀁆􀁋􀁈􀁐􀁌􀁆􀁄􀁏􀀃 􀁗􀁈􀁖􀁗􀁖􀀃 􀁉􀁕􀁒􀁐􀀃 􀁅􀁒􀁗􀁋􀀃 􀁊􀁕􀁒􀁘􀁓􀁖􀀃 􀁚􀁈􀁕􀁈􀀃 􀁒􀁅􀁖􀁈􀁕􀁙􀁈􀁇􀀃 􀁖􀁌􀁐􀁌􀁏􀁄􀁕􀀃 􀁏􀁈􀁙-􀁈􀁏􀁖􀀃􀁒􀁉􀀃􀁊􀁏􀁘􀁆􀁒􀁖􀁈􀀃􀀋􀀦􀀃􀁊􀁕􀁒􀁘􀁓􀀝􀀃􀀔􀀗􀀓􀀑􀀚􀀃􀁐􀁊􀀒􀁇􀁏􀀃􀀎􀀃􀀕􀀛􀀑􀀗􀀃􀀒􀀃􀀩􀀃􀁊􀁕􀁒􀁘􀁓􀀝􀀃􀀔􀀔􀀛􀀑􀀖􀀃􀁐􀁊􀀒􀁇􀁏􀀃