Eca20 microsatellite polymorphisms in Equine Viral Arteritis infected horses from Argentina

KALEMKERIAN PB; METZ GE; LOPEZ GAPPA J.; PERAL GARCIA P; ECHEVERRÍA MG; GIOVAMBATTISTA G; DIAZ S

TISSUE ANTIGENS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 p. 1 - 4

0001-2815

We investigated the association of Equine Arteritis Virus (EAV) infection and three STR polymorphisms located within or in close proximity to Equine Lymphocyte Antigen region (ELA). We used a case-control design as a first approach before proceeding to select candidate genes. One hundred and sixty five Silla Argentino horses were taken in 2002 from positive serological detections of EAV in Argentina, to determine whether STR genotypes were correlated to genetic susceptibility to EVA. Allele frequency distribution did not show significant differences between both groups (p= 0.0781). However, in particular alleles, Fisher?s exact test and OR calculations showed significant values for TKY08 and LEX52, and < 1 for UM011,TKY08, LEX52 and VHL20. Interestingly, TKY08 STR is located in ELA class I region.