INVESTIGADORES
CUTIN Edgardo Hugo
artículos
Título:
Conformational changes of 3,5,3'- triiodo L-thyronine induced by interactions with phospholipid: Physiological speculations.
Autor/es:
EDGARDO HUGO CUTIN; ÁLVAREZ, RSM; R.N.FARIAS
Revista:
Journal of Membrane Biology
Editorial:
Springer Science
Referencias:
Año: 2005 vol. 205 p. 61 - 69
ISSN:
0022-2631
Resumen:
The conformational changes of 3,5,3¢-triiodo L-thyronine induced by interaction with phospholipids were analyzed by Raman spectroscopy. The spectra were interpreted in terms of two conformers of this hormone in equilibrium in the lipid medium, depending on the orientation of the 3¢-iodine with respect to the ring a. Theoretical geometry optimizations on both conformers in vacuo and in different solvents, together with the respective calculated energies support the experimental results. The presence of only one iodine atom in the phenolic ring allows assumption of a higher flexibility of 3,5,3¢- triiodo L-thyronine and a better commodation into the lipid medium compared to 3,5,3¢,5¢-tetraiodo Lthyronine. The possible physiological implications of structural differences that appear in membrane models between 3,5,3¢-triiodo L-thyronine and 3,5,3¢,5¢-tetraiodo L-thyronine are discussed.
