Allogenic stimulus induces prostaglandin and thromboxane production in T lymphocytes.

GENARO AM; CREMASCHI GA; BORDA ES

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 1989 vol. 38 p. 203 - 206

0952-3278

We have examined the influence of an allogeneic stimulus on T lymphocyte prostanoid synthesis. PGE2 and TXB2 (the stable product of TXA2) were determined by radioimmunoassay. When T cells were derived from alloimmunized animals, the production of PGE2 and TXA2 was significantly higher than that of non-immunized cells. Moreover, T immune lymphocytes in the presence of the immunized alloantigen showed an increment in prostanoid production. We propose that the allogeneic stimulus provides a signal to the T lymphocytes for an increase in prostanoid synthesis.