INVESTIGADORES
CORREA Silvia Graciela
congresos y reuniones científicas
Título:
Circadian clock control of gut homing receptor expression
Autor/es:
BARRIOS BE, MACCIO MARETTO L, NOVOTNY NUÑEZ I, CORREA SG.
Lugar:
Los Cocos Cordoba
Reunión:
Workshop; Advanced Course on Mucosal Immunology-Society for Mucosal Immunology; 2018
Institución organizadora:
Society for Mucosal Immunology
Resumen:
In the intestine, the circadian clock orchestrates the temporal organization of many aspects of physiology including immunity. As gut homing receptors (gHR) direct cells towards effector sites, variations in the intestinal environment over a circadian period could modulate the trafficking phenotype of immune cells. We analyzed gHR expression over 24h in MLN lymphocyte subpopulations in C57BL/6 mice housed in 12:12 light-dark conditions at different times (ZT5, 11, 17 and 23) using flow cytometry. In B cells, increments of the α4β7 integrin and CCR9 were observed at ZT17 and ZT11, respectively (p
