Minthostachys verticillata essential oil orally administered modulates gastrointestinal proinflammatory parameters in mice.

MONTIRONI ID, CAMPRA NA, ARSAUTE S, CECCHINI ME, RAVIOLO JM, VANDEN BRABER N, BARRIOS B, MONTENEGRO M, CORREA S, GROSSO MC, MAÑAS F, BELLINGERI RV, CARIDDI LN

Congreso; Reunión de Sociedades de Biociencias 2021-LXIX Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2021

Farm animals are exposed to stressors that alter oxidative and immunological balance, affecting the gastrointestinal system. Minthostachys verticillata essential oil (EO) has shown antioxidant andimmunomodulating activities and could be a natural alternative to improve animal health. The aim of this study was to evaluate the impact of EO oral administration on gastrointestinal proinflammatory parameters. For this purpose, three groups of male Balb/c mice(n=3) were orally administered with saline solution (control group) and EO (5 or 10 mg/kg/day) during 10 consecutive days. Subsequently, histological parameters, cytokines production and oxidative markers were evaluated. The results indicated that EO (5 mg/ kg/day) improved mice growth performance compared to control and EO (10 mg/kg/day) groups (p