Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and Epilachna paenulata and Quantitative Structure -Activity analysis

MONTENEGRO, I.J.; DEL CORRAL, S.; DIAZ NAPAL, GEORGINA N.; CARPINELLA M. C.; MELLADO, M.; MADRID, A.M.; VILLENA, J. ; PALACIOS S. M.; CUELLAR, M.

PEST MANAGEMENT SCIENCE

JOHN WILEY & SONS LTD

Lugar: LOndres; Año: 2018 vol. 74 p. 1623 - 1629

1526-498X

BACKGROUND: The antifeedant activity of 18 sesquiterpenoids of the drimane family (polygodial, drimenol and derivatives) was investigated. The results of this study against two insect species, Spodoptera frugiperda and Epilachna paenulata showed that polygodial, drimanic and nordrimanic derivatives exert antifeedant effects in these pests of agronomic interest indicating that they have potential as a biopesticide agent. RESULTS Among the 18 compounds tested, the epoxynordrimane compound (11) and isonordrimenone (4) showed itself the highest activity (EC50 = 23.28 and 25.63 nmol/cm2 , respectively against S. frugiperda; and 50.50 and 59.00 nmol/cm2 , respectively against E. paenulata). CONCLUSION: The results of the present study suggest that drimanic compounds against could arise as new agents for the treatment of S. frugiperda and E. paenulata. A QSAR analysis of the whole series, supported by electronic studies suggest drimanic compounds have structural features necessary for increasing the antifeedant activity namely a C-9 carbonyl group and epoxide at C-8 and C-9 group.