Tumor effect on its adipose microenviroment in human breast cancer: An immunohystochemical study

FLETCHER, S.J.; SACCA, P.A.; CROSBIE, M.L.; URSINO, A.; SANTISO, N.; FRASCAROLLI, M.C.; GUTIÉRREZ, A.; AMATO, A.R.; DRESZMAN, R.; CARON, R.W.; CALVO, J.C.; PISTONE-CREYDT, V.

Mendoza

Congreso; XXXIV Reunión Científica anual de la Sociedad de Biología de Cuyo; 2016

Sociedad de Biología de Cuyo

Tumor stroma is one of the emerging topics of interest in cancer research. In breast cancer, tumor epithelial cells interact dynamically with different stromal cells. This interaction has been shown to be crucial for tumor progression and dissemination. Adipose tissue is the main component of the breast stroma. Therefore, in this study we aim to identify the effect that breast tumors have on their adipose microenvironment. For this we collected samples of human breast adipose tissue from tumor breasts (hATT) of patients with cancer and from normal breasts (hATN) of healthy women. The explants were fixed with formaldehyde 4%, embedded in paraffin and sliced for immunohistochemical analysis. We found that adiponectin (one of the major adipokines and with anti-tumorigenic effects) expression was significantly increased in hATN vs hATT (p