EFFECT OF YERBA MATE ON IN VIVO AND IN VITRO MODELS OF PROSTATE CANCER

SANTIANO, F.E.; REY, L.S.; ZYLA, L.E.; GÓMEZ, S.E.; BRUNA, F. A.; CAMPO VERDE ARBOCCO, F.; SASSO, C.V.; PISTONE CREYDT, V.; PÉREZ ELIZALDE, R.; LÓPEZ-FONTANA, C.M.; CARON, R.W

Congreso; XXXIX Reunión Cientifica Anual de la Sociedad de Biología de Cuyo; 2021

Sociedad de Biología de Cuyo

The consumption of mate (YM) has been associated with numerous health benefits due to its antioxidant, vasodilator, anti-inflammatory, antimutagenic and lipid-lowering properties. This protective effects can be attributed to the activity of the bioactive compounds in mate: chlorogenic acid, caffeine, rutin and quercetin. Since YM infusion is the one most consumed in Argentina, it is necessary to expand the study of its effects on health and the development of human diseases. Prostate cancer (CaP) is the most frequent carcinoma in men and has a latency period of approximately 25 years, which provides a time long enough to carry out prevention. Therefore, the objective of this work was to expand the study of the anticancer potential of YM characterizing the influence and molecular mechanisms of YM on the development of CaP. On one hand, we established an in vitro model to study the direct effects of mate on the proliferation, viability, and migration of three human CaP cell lines with different aggressiveness and hormonal dependence: LnCaP, PC3 and DU145. On the other hand, we developed an in vivo model of CaP through subcutaneous inoculation of TRAMP-C1 cells in C57BL/6 mice, to evaluate the influence of mate consumption on tumor development. Subsequently, the animals were divided into two study groups: Mate (50 mg/ml of mate in drinking water, n=12), and Controls (only drinking water, n=12). Our in vitro results showed that YM decreased the viability and proliferation of the three tumor cell lines studied (p