Natural Snake Venom inhibitors and their pharmaceutical uses: challenges and possibilities

SAAVEDRA, SOLEDAD L.; ÁVILA, LUCÍA; GIUDICESSI, SILVANA L.; ALBERICIO, FERNANDO; CAMPERI, SILVIA A.; CASCONE, OSVALDO; MARTINEZ CERON, MARÍA C.

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2018 vol. 24 p. 1737 - 1747

1381-6128

Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms.