Pharmacokinetics and Residues of Cloxacillin in Milk of Lactating Dairy Cows After Intramammary Administration.

JUAN RODRÍGUEZ PÉRSICO; FLORENCIA ALIVERTI; LAURA MARCHETTI; MARISA MARTÍNEZ; DANIEL BULDAIN; LAURA ARAUJO; NORA MESTORINO; MARIANA LUCAS; ANDREA BUCHAMER

Tucson, Arizona

Congreso; National Mastitis Council 57th Annual Meeting; 2018

National Mastitis Council

Cloxacillin (CLOX) is frequentlyused in the treatment and prevention of mastitis caused by S. aureus. The effectiveness of antimicrobial therapy in mastitis depends on several factors such asantimicrobial agent(ATM), formulation, dose, administration route and duration of treatment, among others (Mestorino, 2012). Consequently ourobjectives were: i)To evaluate the pharmacokinetic behavior of CLOX in milk afterintramammary (IMM) administration of 5 applications,every 12 hours of a formulation based on CLOX-sodium (UBRESAN LAC 200, Biogénesis Bagó) to high and low producing dairycows; ii) To determine the CLOX withdrawal time in milk once the treatment regimen mentioned has been completed.