Craniofacial growth modification resulting from postnatal nutritional rehabilitation in rats with intrauterine growth retardation

LUNA ME; QUINTERO FA; CESANI MF; FUCINI MC; GUIMAREY LM; VILLANUEVA M; PRIO V; OYHENART EE

La Plata

Congreso; XIV Congreso y 11avas Jornadas de Educación; 2012

Sociedad de Ciencias Morfológicas

The aim was to analyze the effect of lactational and post-lactational nutritional rehabilitation of cranial growth in rats with intrauterine growth retardation. Wistar rats were divided into Control (C) and Intrauterine Growth Retardation (IUGR) groups. The IUGR group was constituted by offspring whose mothers received partial ligation of both uterine arteries at day 15 of gestation. The mothers during gestation and lactation as well as the offspring during post weaning were fed on stock diet ad libitum. The animals were x-rayed at day 1, 21 and 84 of postnatal life. Neurocranial and splachnocranial length, width and height were measured on each radiograph. Neural (NVI) and facial (FVI) volumetric indices were calculated. Kolmogorov-Smirnov test, multivariate analysis of variance, least squared post hoc test and discriminant analysis (DA) were performed. The results indicated significant differences between C and IUGR groups for age, sex and treatment. In the comparison between C and IUGR NVI and FVI showed at birth significant differences in both sexes, and at 21 days in males. At last (84 days) males had significant differences only in NVI and females in NVI and FVI. The DA differentiated treatment and sex in all ages. The results obtained show the effect caused by prenatal stress, even when mediating nutritional rehabilitation. Cranial recovery depends on the sex and the region analyzed. In males, facial compensatory growth occurs belatedly. Even though the females recovered cranial size during lactation then they presented growth retardation newly.