INVESTIGADORES
APPIGNANESI Gustavo Adrian
artículos
Título:
?Comment on: Glass transition in biomolecules and the liquid-liquid critical point of water''
Autor/es:
S. ACCORDINO; D. C. MALASPINA; J. A. RODRÍGUEZ FRIS; G. A. APPIGNANESI
Revista:
PHYSICAL REVIEW LETTERS
Editorial:
AMER PHYSICAL SOC
Referencias:
Lugar: New York; Año: 2011 vol. 106 p. 29801 - 29801
ISSN:
0031-9007
Resumen:
A recent Letter [1] investigated the relationship between
dynamic transitions of biomolecules (lysozyme and DNA)
and dynamic and thermodynamic properties of hydration
water. This seminal work demonstrated that the so-called
??protein glass transition?? is (in two ways) ill-defined: It
is not properly a glass transition nor due to the protein?s
behavior. Rather, this phenomenon is shown to occur at the
dynamic crossover in the diffusivity of the hydration water
as a result of crossing the hypothesized liquid-liquid critical
point (Widom line). One piece of evidence provided
was the demonstration that the rate of change with temperature
of the local order of hydration water molecules
for both lysozyme and DNA presents a maximum at such
crossover temperature [1]. However, there exist two problems
on their way to this result which could lead to misleading
results.
on their way to this result which could lead to misleading
results.
dynamic transitions of biomolecules (lysozyme and DNA)
and dynamic and thermodynamic properties of hydration
water. This seminal work demonstrated that the so-called
??protein glass transition?? is (in two ways) ill-defined: It
is not properly a glass transition nor due to the protein?s
behavior. Rather, this phenomenon is shown to occur at the
dynamic crossover in the diffusivity of the hydration water
as a result of crossing the hypothesized liquid-liquid critical
point (Widom line). One piece of evidence provided
was the demonstration that the rate of change with temperature
of the local order of hydration water molecules
for both lysozyme and DNA presents a maximum at such
crossover temperature [1]. However, there exist two problems
on their way to this result which could lead to misleading
results.
on their way to this result which could lead to misleading
results.
1] investigated the relationship between
dynamic transitions of biomolecules (lysozyme and DNA)
and dynamic and thermodynamic properties of hydration
water. This seminal work demonstrated that the so-called
??protein glass transition?? is (in two ways) ill-defined: It
is not properly a glass transition nor due to the protein?s
behavior. Rather, this phenomenon is shown to occur at the
dynamic crossover in the diffusivity of the hydration water
as a result of crossing the hypothesized liquid-liquid critical
point (Widom line). One piece of evidence provided
was the demonstration that the rate of change with temperature
of the local order of hydration water molecules
for both lysozyme and DNA presents a maximum at such
crossover temperature [1]. However, there exist two problems
on their way to this result which could lead to misleading
results.
on their way to this result which could lead to misleading
results.
1]. However, there exist two problems
on their way to this result which could lead to misleading
results.