INVESTIGADORES
APPIGNANESI Gustavo Adrian
artículos
Título:
Finding the collapse-inducing nucleus in a folding protein
Autor/es:
A. FERNÁNDEZ; G. A. APPIGNANESI; A. COLUBRI
Revista:
JOURNAL OF CHEMICAL PHYSICS
Editorial:
AMER INST PHYSICS
Referencias:
Lugar: American Institute of Physics; Año: 2001 vol. 114 p. 8678 - 8684
ISSN:
0021-9606
Resumen:
Coarse-grained dynamic computations of a widely studied system as BPTI were carried out. A folding scenario was found whereby the structural fluctuations in the molecule are only suppressed once a nucleus is formed. An analysis of the time-dependent thermodynamic as well as kinetic data revealed that this nucleus is the result of a rough search in conformation space.
