INVESTIGADORES
AOKI Maria Del Pilar
congresos y reuniones científicas
Título:
Spleen B cells from BALB/c mice are more prone to activation than C57BL/6 during a secondary immune response.
Autor/es:
PELLEGRINI A; GUIÑAZÚ NL; AOKI MP; CHICO GALERO I; CARRERA SILVA A; GIRONÉS, NURIA; FRESNO M; GEA S
Lugar:
Rio de Janeiro
Reunión:
Congreso; 13º Congreso Internacional de Inmunología (ICI); 2007
Institución organizadora:
Sociedades Científicas
Resumen:
There is
increasing interest in the study of roles that B cells may play in
regulating immune responses both in protection and pathogenesis.
However, little is known about additional immune functions of B cells
independently of Ab production. In this study we have assessed how the
immunization with T dependent Ags in different host genetic backgrounds
affect several parameters of B cells during secondary immune responses.
We have previously reported that BALB/c immunized with cruzipain,
induced heart autoimmunity whereas C57BL/6 mice were resistant. In a
comparative study employing the same experimental model, we demonstrated
that BALB/c enriched spleen B cells presented higher ability to
proliferate releasing elevated levels of IL-4. Moreover, spleen of
immune BALB/c mice presented an increased number of germinal center and
plasma cells as well as higher expression of B cell activation markers
(MHC-II, CD40, CD86). Through the employment of IL-4 or IFN-��R
KO mice in this model, we provided evidence supporting the differential
effect of these cytokine signals in MHC-II and CD86 expression on B
cells. These findings demonstrate the influence of genetic background on
B cell activation and emphasize the importance of examining B cells
behaviour in the context of the specific immunogens.