Associations between Objectively Measured Physical Activity, Sedentary Time and Cardiorespiratory Fitness with Inflammatory and Oxidative Stress Markers and Heart Rate Variability

DEL ROSSO, SEBASTIÁN; BERGERO, G; BARAQUET, L; MUÑOZ, F; MAZZOCCO, YL; AOKI, MP; PEROVIC, N

Journal of Public Health Research

GEnotech

Año: 2022

Purpose: To assess the associations between physical activity (PA) and sedentary time (SEDT) with inflammatory and oxidative stress markers, heart rate variability (HRV) and post-exercise recovery (HRR) controlling for cardiorespiratory fitness (CRF) and potential confounders. Methods: The following data was collected from 44 participants [66% women, age=49.56.4 years, BMI=28.16.2 kg·m-2,]: Plasma levels of C-reactive protein (CRP), and cytokines (IL-1β, INF-γ, TNF-α, MCP-1, IL-6, IL-8, IL-10, IL-18, IL-23); plasma catalase (CAT) and glutathione peroxidase (GPX) activities; resting heart (HR) rate for HRV analysis (time and frequency domains, non-linear, PNS and SNS Index), anthropometric measures, a submaximal cycling test to evaluate CRF with active recovery to assess and HRR (kinetics, absolute and ΔHR), and 7-day PA monitoring by accelerometry.Results: Compared to men, women spent more SEDT (P=0.035, ES=0.72), with less sedentary breaks (P=0.014, ES=0.43) while exhibited higher ln IL-6 (P=0.02, ES=0.84) and ln TNF-α (P=0.01, ES=0.97) with lower HRV indices [SDNN, LF/HF, SD2 (P>0.05)]. Significant adjusted associations were found between SEDT and ln CRP [B=0.006, P=0.001] and ln MCP-1 [B=0.003, P=0.038]. HRV indices were not related to PA or SEDT while HRR was positively associated with light PA [Δ3 (B=0.051, P=0.043), Δ4 (B=0.062, P=0.021)]. There was an association between some HRV indices and inflammatory/oxidative stress markers [ln IL-10 vs. PNS Index (B=0.046, P=0.04), ln LF vs. GPX (B=-0.47, P=0.014), ln HF vs. ln-IL 23 (B=0.39, P=0.036), and vs. ln CAT (B=-8.90, P=0.026)] while HRR was inversely related to ln CAT [Δ3 (B=-54.7, P=0.042), Δ4 (B=-54.1, P=0.021] and Δ5 vs. ln CRP [B=-19.8, P=0.033]. Higher CRF cluster showed lower values for ln TNF-α (P=0.02) and IL-10 (P=0.003) and better HRV indices [RMSSD, PNS, SampEn, SD1 (P