INVESTIGADORES
ALVAREZ Cecilia Ines
artículos
Título:
Rab1b regulates COPI and COPII dynamics in mammalian cells
Autor/es:
IRIS A. GARCÍA; HERNÁN MARTINEZ; CECILIA ALVAREZ
Revista:
Cellular Logistics
Editorial:
Editor Journal: • Landes Bioscience
Referencias:
Lugar: Austin, TX, USA.; Año: 2011 vol. 1 p. 143 - 147
ISSN:
2159-2799
Resumen:
Rabs GTPases are key regulatory factors that specifically associate to organelles that integrate membrane transport pathways. Rabs, through their interactions with diverse effector proteins, regulate the formation, movement, tethering and fusion of transport carriers (vesicles and/or tubules). The mammalian Rab1b GTPase is required for ER to Golgi transport and interacts with multiple effectors localized at the ER-Golgi interface. Here, we focus on interactions between Rab1b and effectors that play essential roles in COPII and COPI vesicle formation/function. Based on evidence to date, we propose a model of Rab1b action at the ER exit sites.