Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1

CINGOLANI HE; PÉREZ NG; AIELLO EA; ENNIS IL; GARCIARENA CD; VILLA-ABRILLE MC; DULCE RA; CALDIZ CI; YEVES AM; CORREA MV; NOLLY MB; CHIAPPE DE CINGOLANI G.

Frontiers in bioscience

Frontiers In Bioscience Publications

Año: 2008 vol. 13 p. 7096 - 7114

1093-9946

Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. Cingolani HE, Perez NG, Aiello EA, Ennis IL, Garciarena CD, Villa-Abrille MC, Dulce RA, Caldiz CI, Yeves AM, Correa MV, Nolly MB, Chiappe de Cingolani G. The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCX(rev)), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways