INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Proceeding título: Docking study of the sesquiterpene lactone cumanin and its derivatives on trypanothione reductase from Trypanosoma cruzi?
Autor/es:
MARIA FLORENCIA BEER, LUCAS FABIAN, JIMENA BORGO, OSVALDO DONADEL, ALBERTINA MOGLIONI, VALERIA SÜLSEN.
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Año: 2017 vol. 77 p. 343 - 343
ISSN:
0025-7680
Resumen:
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is endemic in Latin America. Trypanothione reductase (TcTR) is an enzyme critical in maintaining the thiol redox balance in trypanosomatids.That is why it is one of the most important antichagasic drug target. Based on the experimental evidence of the trypanosomicidal activity of the sesquiterpene lactone cumanin, acquired by this working group and reported in the literature1, several derivatives were obtainedfrom it.
