Association of Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in a population from San Luis.

CIUFFO G M; CORREA M. MILAGROS; FUENTES LB; ARCE MARÍA E

Mar del Plata

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2016

Sociedad Argentina de Investigación Clínica (SAIC)

Hypertension is associated commonly with stroke and cardiovascular disease, leading to significant morbidity and mortality. Epidemiological studies reported that environmental factors could contribute to the risk of essential hypertension (EH), and suggested that is a complex disease resulting from the interactions of genes and environmental factors. The renin?angiotensin system (RAS) may play a crucial role in the regulation of blood pressure and pathogenesis of EH. Genetic polymorphisms in the RAS genes, such as angiotensinogen, angiotensin II type-1 receptor (AT1) and angiotensin-converting enzyme have been investigated as potential genetic factors involved in EH. The aim was to analyses the association between EH and the main genetic polymorphisms A1166C of AT1 in hypertensive and normotensive individuals from San Luis (Argentina). 112 patients were selected from general population of our community during 2015. Ethics committee approval the study and informed consent was obtained. Hypertensive subjects 57 (49% women), age 54.5±8.6 years, systolic and diastolic blood pressure 152.7±17.8/88.9±11.1 mmHg respectively. Normotensive individuals 55 (69% women), age 40.8±15.6 years, systolic and diastolic blood pressure 116.8±11.3/69.8±10.1 mmHg. The A1166C polymorphism was analyzed by PCR-RFLP and biochemical parameters were determined. Frequency genotypes in hypertensive / control: AA 43.9/58.2%, AC 43.9/32.7% and CC 12.3/9.1%, alleles frequency A1166 0.65/0.75 and C1166 0.35/0.25. Chi square analysis shows genotypic CC was statistically significant in hypertensive women > 38 years (p