Effects of Captopril during last week of gestation in pup?s lung development.

COMFORTI ROCIO AYELEM; CIUFFO GM; SOLER GARCÍA F; FUENTES LUCIA BEATRIZ; SANCHEZ SUSANA INES

Mar del Plata. Buenos Aires

Congreso; REUNIÓN CONJUNTA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC), SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) Y SOCIEDAD ARGENTINA DE FARMACOLOGÍA EXPERIMENTAL; 2016

Sociedad Argentina de Farmacología experimental

Lung development is a complex process that involves coordinated action of multiple genes and the participation of numerous transcription and growth factors. The rat lung organogenesis begins in the embryonic stages and ending two weeks postnatal. Angiotensin II is a multifunctional hormone that manifests its properties by interacting with two major subtypes of cell surface receptors AT1 and AT2. Different components of renin angiotensin system(RAS) are expressed in development lung suggesting a possible involvement during lung development. Angiotensin converting enzyme (ACE) inhibitors are able to modify the actions of the RAS and are indicated for the treatment of hypertension. When ACE inhibitors were used in the second half of pregnancy, they can cause several abnormalities: fetal growth retardation, pulmonary hypoplasia and others.The aim of this study was to test the effects of Captopril during last week of gestation in rat?s lung development. Pregnant rats at 13 day of pregnancy were treated with captopril (2,85 mg/kg/day)and isotonic vehicle solution as control and pup`s lung were examined at day 0, 8 and 15(P0, P8, P15).Lung development was evaluated by histological analysis.Histopathology of the pup?s lungs shows altered development of the lung parenchyma, conducting airways and pulmonary vasculature. The evaluation in distal parenchyma from captopril treated group showed impaired alveolar formation, enlargement of distal airway space at P8 y P15 (p