Effect of TNFRp55 deficiency on the inflammatory process exhibited at the end of pregnancy.

ARIAS JOSÉ LUIS; RAGUSA JOSÉ ANTONIO; CARGNELUTTI ETHELINA; CASAIS MARILINA; ANZULOVICH ANA CECILIA; DI GENARO MARIA SILVIA

POTRERO DE LOS FUNES, SAN LUIS.

Congreso; 47º REUNION ANUAL SOCIEDAD ARGENTINA DE INVESTIGACION EN BIOQUIMICA Y BIOLOGIA MOLECULAR; 2011

SOCIEDAD ARGENTINA DE INVESTIGACION EN BIOQUIMICA Y BIOLOGIA MOLECULAR

Tumor necrosis factor is a pleotropic pro-inflammatory cytokine and TNF receptor p55 (TNFRp55) mediates most of the TNF effects. Pregnancy, either with or without signs of infection, show elevated levels of pro-inflammatory cytokines in maternal serum and fetal membranes when parturition is imminent. How this inflammatory milliu could impact on the maternal synovial membrane has not been investigated. Our objective was to study the consequences of TNFRp55 deficiency on the interleukine(IL)-17 and progesterone (Pg) levels in the joint of C57BL/6 wild type (WT) and TNFRp55-/- (KO) mice. IL-17 and Pg were determined by ELISA and RIA, respectively. We found elevated levels of IL-17 at the end of pregnancy in WT mice compared to diestrous stage. Moreover, IL-17 levels were lower in KO than WT mice at the end of pregnancy (p