DIETARY SALVIA HISPANICA L. REDUCES CARDIAC OXIDATIVE STRESS of DYSLIPEMIC INSULIN-RESISTANT RATS

CHICCO ADRIANA; LOMBARDO Y; ALVAREZ SM; CREUS AGUSTINA; GIMENEZ MS

APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM

NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS

Lugar: Otawa; Año: 2020

1715-5312

Salvia hispanica L., commonly known as chia seed, has beneficial effects upon somesigns of metabolic syndrome (MS), such as dyslipidemia and insulin resistance. However,its action on cardiac oxidative stress associated with MS remains unknown. The goal ofthis study was to analyze the possible beneficial effects of chia seed (variety Salba) uponthe oxidative stress of left ventricle heart muscle (LV) of a well established dyslipidemicinsulin-resistant rat model induced by feeding them a sucrose-rich diet (SRD). MaleWistar rats received an SRD for three months. After that, for three additional months, halfof the animals continued with the SRD, while the other half received the SRD containingchia as the source of dietary fat instead corn oil (SRD+chia). In the LV of SRD-fed rats,chia seed improved/reverted the depleted activity of antioxidant enzymes glutathioneperoxidase, superoxide dismutase (SOD), and catalase, and ameliorated MnSOD mRNAlevels increasing the expression of the nuclear factor Nrf2. Improved the glutathioneredox estate, reactive oxygen species, and TBARS contents normalizing the p47NOXsubunit mRNA level. Furthermore, chia normalized hypertension and plasma levels ofpro-inflammatory cytokines and oxidative stress biomarkers. The findings show that chiaseed intake impacts positively upon oxidative unbalance of LV of dyslipidemic insulinresistant rats.