ROLE OF DIFFERENT PROTEIN SOURCES IN THE MORPHOLOGY OF CD INTOXICATED LUNGS

BOLDRINI GG; PÉREZ CHACA MV; MOYANO MF; ÁLVAREZ SM; CIMINARI ME; BIAGGIO VS; GÓMEZ NN; MARTIN MOLINERO GD; FILIPPA V; GIMÉNEZ MS

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2018

SAIC

Cadmium (Cd) is a toxic metal and an important environmentalcontaminant. We studied its effects on morphology, bronchoalveolarlavages (BAL) and LDH activity under different diets. 4 lots offemale Wistar rats were used: 2 lots received casein (Cas) and 2lots received soybean (Soy) as protein sources. Within each group:1 lot received regular water (control-Co) and the other 15ppm of Cdin the drinking water for 60days. BAL was performed, LDH activitywas measured and cells obtained were analysed. Lungs were fixed,sectioned, stained, examined for evidence of injury and analyzedmorphometricaly. A lung section was mineralized and cadmium concentrationwas measured by ICP-MS.Cadmium concentration was higher in intoxicated groups, but onlysignificative in Cas-Cd (p