LUNG PRE-FIBROTIC STATUS IN A MOUSE MODEL OF METABOLIC SYNDROME: IMPLICATION OF OXIDATIVE STRESS AND INFLAMMATION.

MARIA CECILIA DELLA VEDOVA ; DARIO CEFERINO RAMIREZ; SANDRA E. GOMEZ MEJIBA ; NIDIA N. GOMEZ

BS AS

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

SAIC, SAIB, SAI, SAFE, SAA, SAA, SAFIS,

MEDICINA - Volumen 77 - (Supl. I), 2017During the last decades there was a sustained increase in morbidityand mortality due to respiratory and metabolic diseases associatedwith obesity, such as the metabolic syndrome (MS). Componentsof MS, such as dyslipidemia, hyperglycemia, hypertensionand obesity were independently associated with lung function, butfrom all of them, obesity is clearly implicated. Herein we aimed atdetermining the impact of the MS on redox/inflammatory status andpotential consequences in the lung using a previously developedmouse model of MS. To achieve this goal, 6 week-old male C57BL /6J mice were fed for 16 weeks with a low fat- (LFD) or a high fat-diet(HFD, chicken fat) and water supplemented with 10% fructose (F).Thus, the experimental design included 2 groups: LFD (control) HFD+F (MS). At the end of the treatment, lung of the HFD + F groupcompared to the LFD group had an increase in NOX-2 (p