CONICET | Buscador de Institutos y Recursos Humanos

VARIOUS SPECIES OF THE GENERA CANDIDA AND CRYPTOCOCCUS CAN BE INHIBITED COMPARED WITH 1-TOSYL-1H-BENZO [D] IMIDAZOL-2-AMINE AND Cu (II) AND Co (II). Diaz J R A*, Ronchi G**, Floridia R**,González E**, Fernández ?Baldo M A**, Baldoni H*, Camí G E*. *Departamento de Química, ** Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química., Bioquímica y Farmacia, Universidad Nacional de San Luis. jorgediaz.unsl@gmail.com Sulfonamide compounds are widely studied for their pharmacological properties. The aim of the present work was the synthesis of new sulfonamides and metal complexes as such as study their antifungal properties. For this, these synthesized sulfonamides and its complexes were tested for their antifungal activity against eight important pathogenic yeasts strains of clinical relevance of genera Candida and Cryptococcus. The yeast strains were provided from the Department of Mycology of the National Institute of Infectious Diseases Dr. Carlos G. Malbrán, Argentina. For the assessment of antifungal activity, 200 µL of yeast (2.0×106 yeast mL-1) of each strain studied were aseptically inoculated into PDA plates. Cavities of 3 mm were made aseptically and were filled with 50 µL of each synthesized sulfonamide. The plates were incubated at 37ºC for 48 h. After incubation, the zones of inhibition were measured. Regarding antifungal activity, synthesized compounds demonstrated effectiveness for inhibiting the assayed yeasts. The maximum zones of inhibition for synthesized sulfonamides (5, 16, 17 and 18) were observed against Cryptococcus neoformans ATCC 24067 (18±3, 22±3, 20±3 and 15±1 mm, respectively) compared with the others strains of yeasts and positive controls (voriconazole and fluconazole) assayed in the present study. The current research opens a new path for the synthesis of novel sulfonamides and its metal complexes and the process is easy to scale up for biomedical applications.