There is No Time to Waste: Low-Pressure Gas Chromatography?Mass Spectrometry is a Proven Solution for Fast, Sensitive, and Robust GC?MS Analysis

SAPOZHNIKOVA, YELENA; KONSCHNIK, JOSEPH; DE ZEEUW, JAAP; ROUSOVA HEPNER, JANA; LEHOTAY, STEVEN J.; MICHLIG, NICOLÁS

LCGC North America

Advanstar Communications Inc.

Año: 2020 vol. 38

1527-5949

Low-pressure gas chromatography (LPGC) has been known to be advantageous compared to standard GC sinceGiddings first described the concept in 1962, but a practical solution for its use eluded analytical chemists until theyear 2000, when de Zeeuw fashioned a simple guard column restrictor concept to maintain positive inlet pressure for awide-bore analytical column under vacuum. Initially introduced as rapid mass spectrometry (MS), de Zeeuw?s inventionmade LPGC practical in nearly any GC application using MS for detection. Lehotay and associates have demonstratedthe advantageous features, excellent performance, and practical utility of LPGC?MS in dozens of publications since2001. In our experience, LPGC?MS is the most practical and beneficial fast-GC technique available to achieve