Protein acetylation and synaptic composition during Inhibitory Avoidance Long-Term memory consolidation in mouse hippocampus

SEBASTIAN RIVAS; LAURA ESQUIVEL; ANGELES SALLES; JULIA BUSSO; MARIA DEL C. KRAWCZYK; VERONICA BAEZ; MARIANO BOCCIA; RAMIRO FREUDENTHAL

CABA

Simposio; Simposio Fronteras en Biociencia 3; 2018

IBioBA, CONICET ? Partner Institute of the Max Planck Society

Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition in vivo during long term memory consolidation have not been addressed. Here we show that there is a correlation between the synaptic protein acetylation level and the synaptic protein composition at hippocampus during memory consolidation and in cultured hippocampus neurons. We also show that altering the acetylation levels by administration of a lysine deacetylase inhibitor specific for KDAC6 (mainly cytoplasmic) immediately after training facilitates retention at testing. These results suggest that lysine acetylation has a role regulating the synaptic changes that occur during memory consolidation