INVESTIGADORES
FREUDENTHAL Ramiro A. M.
congresos y reuniones científicas
Título:
Synaptic NF-kappa B localization dynamics in learning and memory
Autor/es:
ANGELES SALLES; MARIA LAGOS; MARIANO BOCCIA; MARIANO BLAKE; CARLOS MARIA BARATTI; NICOLETTA CORBI; CLAUDIO PASSANATI; ARTURO ROMANO ; RAMIRO FREUDENTHAL
Lugar:
Huerta Grande
Reunión:
Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2012
Institución organizadora:
San
Resumen:
NF-kappa B activation has been shown to be necessary for long-term memory
consolidation in the mouse inhibitory avoidance learning paradigm. NF-kappa B
is activated in the nucleus of hippocampal cells in a specific temporal window
during consolidation. Previous results showed that the transcription factor is
also present in synaptic terminals. More importantly we found NF-kappa B
strongly bound to membranes of these terminals. This new finding poses the
question, is there a local role for NF-kappa B? And if so, is it essential for
learning and memory? Another pool of NF-kappa B has been found in the
synaptosomal content, and its activation measured through Electro Mobility
Shift Assays (EMSA) is modified during consolidation of shocked mice, when
comparing to naïve and unshocked. The membrane bound NF-kappa B
increases 5 minutes post training only in shocked mice. The re localization of
the transcription factor could implicate a new function of NF-kappa B that might
intervene in the consolidation process. The aim of this research is to study the
dynamics of synaptic NF-kappa B activation during consolidation, discussing
the novel localization of the transcription factor in membranes of synaptic
terminals.