INVESTIGADORES
FREUDENTHAL Ramiro A. M.
congresos y reuniones científicas
Título:
Novel localization of NF-kappa B in mouse forebrain synaptic terminals. Activation dynamics during memory consolidation.
Autor/es:
MARIA LAGOS; MARIANO BOCCIA; MARIANO BLAKE; NICOLETTA CORBI; CLAUDIO PASSANANTI; CARLOS MARIA BARATTI; ARTURO ROMANO; RAMIRO FREUDENTHAL
Lugar:
Huerta grande, Cordoba, Agentina
Reunión:
Congreso; IIRCN; 2010
Institución organizadora:
Taller Argentino de Neurociencias y SAN
Resumen:
NF-kappa B activation has recently been shown to be necessary for long-term memory consolidation andreconsolidation, in the inhibitory avoidance learning in the mouse hippocampus. NF-kappa B is activatedin the cell nucleus in specific temporal windows in both consolidation and reconsolidation. Previousresults showed that the transcription factor is also present in synaptic terminals. This work focuses in thedynamics of its synaptic activation during consolidation, in two different synaptic localizations: soluble inthe synaptic content and, in a pool described for the first time in this work, bound to the cell membrane.The function of this novel localization is discussed.
