The effect of IL-1β on memory reconsolidation is mediated by a reduction in glutamate release, calcium influx and AMPA phosphorylation. Modulation by α-MSH.

MACHADO IVANA; GONZALEZ PATRICIA; VILCAES ALEJANDRO; LASAGA MERCEDES; SCIMONELLI TERESA

Washington

Congreso; Neuroscience 2014; 2014

Society for Neuroscience

The immune system is an important modulator of learning, memoryand neural plasticity. Interleukin 1β (IL-1β), a pro-inflammatorycytokine, significantly affects several cognitive processes. Previousstudies of our group have demonstrated that the intrahippocampaladministration of IL-1β impairs reconsolidation of contextual fearmemory. This effect was reversed by the melanocortin alphamelanocyte-stimulating hormone (-MSH). The mechanismsunderlying the effect of IL-1β on memory reconsolidation have notbeen established yet. Therefore, we examined the effect of IL-1β onglutamate release, calcium influx and the phosphorylation of theGluA1 subunit of AMPA glutamatergic receptor at Serine 831 and845. Besides, we established how these effects could be modulatedby α-MSH.