IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effect of intra-core MK 801 administration in the development of stress-induced reinstatement in extinguished cocaine conditioned animals and its influence on a subsequent cocaine-induced reinstatement
Autor/es:
1. DE GIOVANNI L., VIRGOLINI, M.B., CANCELA L.M.
Lugar:
Buenos Aires
Reunión:
Simposio; Segundo Simposio Franco-Argentino de Neurociencias; 2012
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Effect of intra-core MK 801 administration in
the development of stress-induced reinstatement in extinguished cocaine
conditioned animals and its influence on a subsequent cocaine- induced
reinstatement.
Previous results from our lab showed that MK 801 blocked
the stress-induced reinstatement in extinguished cocaine-conditioned rats
evaluated in a conditioned place preference (CPP) test. In the present experiment,
our goal was to determine if the nucleus accumbens core is implied in this blockade.
Male Wistar rats (220-300 g) were
conditioned with cocaine (10 mg/kg i.p.) during four alternated drug/vehicle sessions
and later extinguished with successive
vehicle associations. On the reinstatement day
animals were intra-core administered with MK 801 (0.75 ul/side) or vehicle, and
subsequently assigned to two groups according to the following treatments: 1) Stressed
animals (SA): 30 min-restraint exposure, and 2) Control animals (CA): left undisturbed
in their home cages. All rats were immediately tested in a CPP apparatus for
stress-induced reinstatement. Three days after the animals were submitted to a
vehicle test and the following day administered with a priming
injection of cocaine (5.0 mg/kg i.p.) and evaluated for drug-induced
reinstatement. The results demonstrate that intra-core MK 801
administration prevented the stress-induced reinstatement in the SA animals and
the cocaine-induced reinstatement in SA and CA animals, suggesting that the
nucleus accumbens core may be a target of common glutamatergic mechanisms for both,
the stress and cocaine-induced reinstatement.