QSAR Analysis of 3-ArylQuinoxaline-2-Carbonitrile 1,4-di-n-Oxide Derivatives as Antiplasmodial Agents

E. VICENTE; P. R. DUCHOWICZ; A. BURGUETE; B. SOLANO; R. VILLAR; S. PÉREZ-SILANES; I. ALDANA; E. A. CASTRO; L. VIVAS; A. MONGE

Vienna

Simposio; XXth International Symposium on Medicinal Chemistry; 2008

Malaria is by far the world’s most important tropical parasitic disease. Mortality, currently estimated at over a million people per year, has risen in recent years. It exacts a heavy toll of illness and death - especially amongst children and pregnant women. It also poses a risk to travellers and immigrants, with imported cases increasing in non-endemic areas. A major drawback in the chemotherapy of malaria is the rapid and widespread development of drug resistance in Plasmodia to most existing antimalarials. This is the reason research was aimed at the development of new antimalarials.