Cholestasis

LUCANGIOLI S.; TRIPODI V.

InTech

Año: 2012 p. 100

978-953-51-0043-0

The aim of this book is the study of cholestasis from different points of view. Cholestasis is one of the most common and devastating manifestations of hereditary and acquired liver diseases. Since the importance of the disease has been made aware, there have been many research works, providing an increase of information. Identification of the molecular defect in cholestasis is not only important for diagnostic reasons, but also to emphasize that impaired transporter function has pathological consequences. Indeed, it is now becoming clear that impaired or down regulated transporter function is also involved in the pathogenesis of acquired cholestatic syndrome. Linked to the diagnosis of cholestasis, an important area to study is the serum bile acid profiles. In this sense, a great development of analytical methodologies has allowed the relationship between them and the different types of cholestasis to be studied. The proper interpretation of serum bile acid profiles provides medical management against the disease. Different models of induction of cholestasis have been designed in order to deepen understanding and clarify protective mechanisms, which could contribute to improved treatment of the pathology. The complete understanding of cholestasis will provide an efficient treatment and an overall improvement in the patient life quality.