INVESTIGADORES
LUCANGIOLI Silvia Edith
congresos y reuniones científicas
Título:
Design and physicochemical stability of glyburide pediatric oral liquid formulations for the treatment of permanent neonatal diabetes
Autor/es:
ESTEVEZ PABLO; BUOMTEMPO F.; QUIROGA E.; BOSCOLO O.; TRIPODI V.; LUCANGIOLI S.
Lugar:
Cordoba
Reunión:
Jornada; 3ª Reunión Internacional de Ciencias Farmacéuticas; 2014
Institución organizadora:
RICIFA
Resumen:
Introduction: Permanent neonatal diabetes mellitus (PNDM) is a rare disease, affecting less than 1% of all cases of diabetes. Several small clinical studies and case reports have demonstrated Glyburide?s efficacy in the treatment of this disease. Since this rare condition is often diagnosed at birth or small age, oral liquid formulations are needed for treatment. Until now, there have been no reports of development and stability studies for Glyburide liquid formulationsPurpose: To study the chemical and microbiological stability of Glyburide formulations, used as therapeutic agent in treatment of PNDM, in two liquid formulations developed: one suspension (2.5 mg/ml) using Glyburide tablets and another suspension (2.5 mg/ml) using Glyburide raw material, both for pediatric use. Furthermore, to optimize and validate a stability-indicating HPLC method for the analysis of Glyburide in the studied formulations.
