DEVELOPMENT OF ORPHAN COENZYME Q10 LIQUID FORMULATIONS FOR PEDIATRIC PATIENS

ESTEVEZ PABLO; TRIPODI V.; BOSCOLO O.; CHIAPPETTA D.; BUOMTEMPO F.; LUCANGIOLI S.

Atenas

Conferencia; 5th BBBB Conference from drugs discovery and formulation strategies to pharmacokinetics ?pharmacodynamic; 2013

National and Kapodistrian University of Athenas

Coenzyme Q10 (CoQ10) deficiency is involved in cardiomyopathies and degenerative muscle and neuronal diseases. Most patients with these deficiencies have shown clinical improvement with oral CoQ10 supplementation especially in pediatric patients. In the case of the active drugs with physicochemical characteristics of poor aqueous solubility, high hydrophobicity and consequently poor absorption like CoQ10, various formulation strategies can be used. The aim of this study was to develop two oil solutions, one of them with the addition of vitamin E and one oil-in-water emulsion of CoQ10 and study the chemical stability of CoQ10 by microHPLC in the proposed extemporaneous formulations stored at room temperature over 110 days.