DEVELOPMENT OF A SELF-EMULSIFYING DRUG DELIVERY SYSTEM CONTAINING COQ10

ZAPICO V; GLUJOY M; BUONTEMPO F; FLOR S; LUCANGIOLI S.; CARLUCCI A

CORDOBA

Encuentro; 1 REUNION INTERNACIONAL DE CIENCIAS FARMACEUTICAS; 2010

RICIFA

Ubiquinone (CoQ10) deficiency is associated with five clinical presentations which showed clinical improvements after oral drug administration (1). Co-Q10 exhibits extreme lipophilicity and high molecular wheight, therefore it is necessary to develop special formulations for its bioavailability. It is well-known that bioavailability can significantly improve using dosage forms which contain CoQ10 dissolved (2).  SEDDS (Self- emulsifying drug delivery system) are isotropic mixtures of oil, surfactant, co-surfactant and drug with ability to form oil in water emulsion upon mild agitation following dilution with aqueous phase (3). The objective of the present work was to optimize a liquid auto emulsifying formulation so as to load a clinical relevant CoQ10 dose to be administered in pediatric patients.