INVESTIGADORES
LUCANGIOLI Silvia Edith
congresos y reuniones científicas
Título:
High-dose Coenzyme Q10 oleogels designed for orphan therapy
Autor/es:
ERENHAUS N.; MARTINEFSKI M.,; HOCHT C.; LUCANGIOLI S.; ROJAS A.; TRIPODI V.
Lugar:
Buenos Aires
Reunión:
Congreso; Drug Discovery for Neglected Diseases International Congress 2018 4 th Scientific Meeting of ResNet NPND; 2018
Institución organizadora:
CONICET - IQUIMEFA
Resumen:
Recently, Coenzyme Q10 (CoQ10) was established by the FDA as an orphan drug and itstherapeutic recommended dose increased significantly, reaching values up to 50 mg/kg/day.Patients with CoQ10 deficiency usually have swallowing difficulties, whereby the use of soliddosage forms is not the best option because they find them hard to swallow resulting in alower adherence to the treatment.In order to satisfy the high-level requirements in adult patients and offer them a morecomfortable way of treatment, a new oral CoQ10 dosage form was developed and evaluated.As CoQ10 is practically insoluble in aqueous solutions because of its lipophilic nature, oleogelswere proposed to dose CoQ10.
